![]() Some studies show that fatigue increases over time throughout the whole pregnancy other studies indicate that fatigue in the first trimester is worse than in the third trimester. Typically, nausea and vomiting begin around gestational weeks 5–8 with peak symptoms occurring around gestational weeks 9 and subsiding around week 12. Causes of nausea, vomiting and fatigue during pregnancy remains unknown rising levels of hormone and stress might be risk factors. Nausea, vomiting and fatigue are the most common symptoms in early pregnancy more than 70% of women have reported the presence of these symptoms in previous studies. We call for awareness of this issue from health care professionals, pregnant women and their families. Our study shows how common nausea, vomiting and fatigue are among women in early pregnancy and how much each of these symptoms negatively impact on health-related quality of life. Comparing with women who never reported nausea, vomiting and fatigue, women with daily presence of at least one of these symptoms had significantly lower scores of physical component summary and mental component summary, after adjusting for potential confounders. 33.6% of women experienced daily presence of nausea, 9.6% for vomiting and 44.4% for fatigue. Multivariate regression models were performed to evaluate the independent associations of the presence of nausea, vomiting and fatigue with health-related quality of life, adjusting for potential confounders. Health-related quality of life was assessed by the 12-item Short Form Health Survey and physical and mental component summary scores were calculated. The information on nausea, vomiting and fatigue in the previous three months was measured in the questionnaire at enrollment, as well as potential confounders (i.e., maternal/gestational age, ethnic background, educational level, parity, marital status, body mass index, tobacco and alcohol use, chronic/infectious conditions, uro-genital conditions/symptoms, sleep quality, headache, anxiety, and depression). ![]() Analyses were based on 5079 women in early pregnancy in the Rotterdam area, the Netherlands. The objective of this study was to evaluate the independent associations between nausea, vomiting, fatigue and health-related quality of life of women in early pregnancy in the Generation R study, which is a prospective mother and child cohort.
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